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阿扎胞苷注射液(AVidaza,Azacitidine Injection,Vidaza)

2012-11-30 22:59:14  作者:新特药房  来源:互联网  浏览次数:195  文字大小:【】【】【
简介:部分中文维达扎处方资料(仅供参考) 【通用名称】阿扎胞苷(5-azacitidine)【药物名称】Ladakamycin(formerly), Azacitidine, U-18496, NSC-102816, Vidaza, Mylosar【化学名称】5-Azacytidine; 4-A ...

部分中文维达扎处方资料(仅供参考)

【通用名称】阿扎胞苷(5-azacitidine)
【药物名称】Ladakamycin(formerly), Azacitidine, U-18496, NSC-102816, Vidaza, Mylosar
【化学名称】5-Azacytidine; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 1-(beta-D-Ribofuranosyl)-5-azacytosine
【化学结构式】

分类名称
一级分类:抗肿瘤药物 二级分类:其他 三级分类: 
 
药品英文名
 
Azacitidine
 
药品别名
 
氮杂胞苷、5-氮杂胞嘧啶核苷、5-Azacytidine、AzGR、Mylosar
 
药物剂型
粉针剂:每支50mg、100mg。用前水溶解为本品浓度5mg/ml和含甘露醇5mg/ml注射液。pH在6.0~7.5之间,在滴注前可进一步在乳酸盐林格注射液中稀释。
 
药理作用
抗肿瘤药,本品在体内先转变成氮杂胞苷酸(AZCRP),可掺入肿瘤细胞RNA和DNA中;能抑制DNA合成,阻碍RNA及蛋白质合成;主要杀伤S期细胞,也可抑制乳酸脱羧酶,使嘧啶的新合成受影响。
 
药动学
静脉给药后血浆生物半衰期为3.5h,85%的放射性在48h内排出。
 
适应证
主要用于治疗髓细胞白血病。及用于乳腺癌、肠癌、黑色素瘤等有一定疗效
 
注意事项
肾功能不全患者慎用。
 
不良反应
有报告2例应用本品治疗发生预料不到的酸碱电解质异常,并有2例死亡。给药200mg/kg,5~7天,多发生多尿、糖尿或暂时的血液中碳酸氢盐或磷酸盐的改变,提示肾小管功能不全。
 
用法用量
静脉滴注:每天50~200mg/kg,连用5天。
 
专家点评
22例接受2个疗程以上的治疗,其中7例难治性急性粒细胞白血病完全缓解(32%),3例部分缓解(14%)。

Azacitidine
Chemical formula:
Azacitidine injection
What is Azacitidine injection?
AZACITIDINE (Vidaza™) is a chemotherapy agent used to treat myelodysplastic syndromes and may be used to treat some types of leukemia. Azacitidine interferes with the growth of rapidly dividing cells, like cancer cells, and eventually causes these cells to die. Generic azacitidine injections are not available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• dental disease
• infection (especially viral infections such as chickenpox or herpes)
• kidney disease
• liver disease
• an unusual reaction to Azacitidine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should this medicine be used?
Azacitidine is given as an injection under the skin by a trained health care profesiional. It has also been given by an infusion into a vein. Azacitidine is usually administered in a hospital or clinic setting.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What drug(s) may interact with Azacitidine?
• vaccines
Talk to your prescriber or health care professional before taking any of these medicines:
• aspirin
• acetaminophen
• ibuprofen
• naproxen
• ketoprofen
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking Azacitidine?
Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood checks. The side effects can continue after you finish your treatment; report side effects promptly.

Azacitidine may make you feel generally unwell. This is not uncommon because azacitidine affects good cells as well as cancer cells. Report any side effects as above, but continue your course of medicine even though you feel ill, unless your prescriber or health care professional tells you to stop.
Azacitidine may decrease your body's ability to fight infections. Call your prescriber or health care professional if you have a fever, chills, sore throat or other symptoms of a cold or flu. Do not treat these symptoms yourself. Try to avoid being around people who are sick. Azacitidine may increase your risk to bruise or bleed. Call your prescriber or health care professional if you notice any unusual bleeding. Be careful not to cut, bruise or injure yourself because you may get an infection and bleed more than usual.
Avoid taking aspirin, acetaminophen (Tylenol®), ibuprofen (Advil®), naproxen (Aleve®), or ketoprofen (Orudis® KT) products as they may mask a fever, unless instructed to by your prescriber or health care professional.
Be careful brushing and flossing your teeth or using a toothpick while receiving azacitidine because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving azacitidine.
There is a possibility that azacitidine could cause harm to an unborn child; this applies to both men and women. If you are pregnant or you or your partner are considering getting pregnant, talk to your health care provider about the risks of azacitidine therapy. Women or men whose partner may have children should use appropriate birth control methods during azacitidine therapy. Discuss possible methods of birth control with your health care provider.
If you are going to have surgery or dental work, tell your prescriber or health care professional that you are using azacitidine.

What side effects may I notice from receiving Azacitidine?
The side effects you may experience with azacitidine therapy depend upon the dose, other types of chemotherapy or radiation therapy given, and the disease being treated. Not all of these effects occur in all patients. Discuss any concerns or questions with your prescriber or health care professional.
Side effects that you should report to your prescriber or health care professional as soon as possible:
• low blood counts - azacitidine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
• signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
• signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
• signs of decreased red blood cells - unusual weakness or tiredness, fainting spells, lightheadedness
• reactions at the injection site including redness, pain, itching, or bruising
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation
• diarrhea
• fatigue
• headache
• loss of appetite
• nausea, vomiting
• skin rash, itching
• stomach pain
• water retention
Where can I keep my medicine?
This does not apply. You will only receive this medicine in a hospital or clinic setting and will not need to store it at home.

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注:以下产品不同规格和不同价格,购买时请以电话咨询为准!
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产地国家: 美国
原产地英文商品名:
VIDAZA 100mg/Vial 10Vials/box
原产地英文药品名:
AZACITIDINE
原产地英文化合物名称:
4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
中文参考商品译名:
维达扎 100毫克/瓶 10瓶/盒
中文参考药品译名:
阿扎胞苷
中文参考化合物名称:
5-氮杂胞嘧啶核苷
曾用名:
阿扎胞苷、5-氮杂胞苷、5-氮杂胞嘧啶核苷、氮胞苷、氮杂胞苷、Ladakamycin
生产厂家中文参考译名:
CELGENE
生产厂家英文名:
CELGENE


--------------------------------------------------------------
产地国家: 美国
原产地英文商品名:
VIDAZA 100mg/Vial
原产地英文药品名:
AZACITIDINE
原产地英文化合物名称:
4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
中文参考商品译名:
维达扎 100毫克/瓶
中文参考药品译名:
阿扎胞苷
中文参考化合物名称:
5-氮杂胞嘧啶核苷
曾用名:
阿扎胞苷、5-氮杂胞苷、5-氮杂胞嘧啶核苷、氮胞苷、氮杂胞苷、Ladakamycin
生产厂家中文参考译名:
CELGENE
生产厂家英文名:
CELGENE

阿扎胞苷注射液(AVidaza,Azacitidine Injection,Vidaza) 咨询

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